High MCV with High Vitamin B12 Levels

My blood results for MCV were 100.4 H. Is that high enough to be concered about? My B12 results were high also at 1180. It doesn't make sence that my B12 would be high if my MCV was high does it?


My iron results were low at 32 L and my % saturation was low at 10 L. Do you have any suggestion for further testing or what the cause of the high MCV is? I do take a B12 supplement daily. Should I quite taking it? Thanks for your help!

Comments for High MCV with High Vitamin B12 Levels

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You have the MTHFR Gene
by: Kerri Knox, RN

Hi Sharon,

If you are taking Vitamin B12, then your B12 level is going to be high. Period. There is no point in getting a Vitamin B12 level if you are taking Vitamin B12. It's worthless. Since you are taking Vitamin B12, and your level is high, but you still have a high MCV Level, then:

A) You have not taken the Vitamin B12 for long enough or
B) You are not taking enough Vitamin B12.

A third possibility is that you have the MTHFR Gene. Having Macrocytic Anemia along with a high Vitamin B12 Level is a 'classic' presentation of inability to process Vitamin B12 due to the MTHFR Gene. But only high Vitamin B12 levels in ABSENCE of taking Vitamin B12 is significant. High B12 levels when you are taking Vitamin B12 is meaningless, and levels should never be taken when one is on Vitamin B12 because it will always be high, but the high level is meaningless and should be ignored.

If you want to find out for sure, then your next step should be to do the extremely inexpensive 23 and Me Genetic Test to find out for sure.



Kerri Knox RN

Kerri Knox, RN- The Immune System Queen
Functional Medicine Practitioner
Immune System
Side Effects
MTHFR
by: Anonymous

If the MTHFR gene is present and not functioning properly, then what can be done to reverse the marcocytic anemia?
Blood work
by: Anonymous

Hello my hemoglobin was 163
Hct 0.48
Mcv 102
Mch 35

Why would it be 2 points higher than the normal range of 89-100 for mcv
see my page
by: Kerri Knox

See my page on MCV Blood Test

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